If you cannot get or keep an erection during intercourse, chances are you have got erectile dysfunction (ED). According to research 51% of men in the U.S. are not satisfied with their sex lives. Erectile dysfunction can occur at any age, it is very rare in young men, and very common in older men. By the age of 40-50, most men will have had some form of ED.
There are many causes of erectile dysfunction:
inflammatory diseases of the genitourinary system, diabetes, hormonal disorders, various spinal injuries, injuries of the penis, surgery on the pelvic organs, taking certain medications, depression, stress. Erectile dysfunction (depending on the causes) manifests itself in two main forms: organic and psychological.More recently, surgery was the only way to treat of organic forms of erectile dysfunction. Now, modern medicine has a wide variety of methods of treatment of impotence, and oral medications seem most popular.
Drugs belonging to the class of inhibitors phosphodiesterase type 5 (PDE5), are considered the most successful ED treatment.
Inhibitors of PDE5. The principle of action
Phosphodiesterase type 5, or PDE5 – is a chemical compound that is produced by the body to suppress another chemical compound – nitric oxide. Nitric oxide relaxes and expands the arteries in the pelvis, resulting to increase blood flow to the genital area. If the body produces too much PDE5, an erection is violated. Inhibitors of PDE5, getting into the body inhibit the enzyme PDE5 a few hours. During this time, nitric oxide has time to accumulate in the arteries and fill with blood the penis. This is the process of erection. When the effect of inhibitors over, enzyme PDE5 stops the action of nitric oxide, the arteries in the genital area again narrowed and the erection disappears.
The most popular inhibitors of PDE5 – is Viagra, Cialis and Levitra.
PDE5. Side-effects
You may experience headache, flushing, dizziness, dyspepsia, nasal congestion, visual disturbances (changes the color of objects (blue / green), increased perception of light, blurred vision), nausea, stomach upset, heartburn. People suffering from diabetes, various cardiovascular diseases, high cholesterol, certain eye problems, as well as people over 50 years is the most susceptible to side effects. In addition, the side effects PDE5 may increase if it’s taken together with alcohol.
Sexual activity may provide additional strain on the heart. If you have heart problems, then after taking the drug you may experience chest pain, severe dizziness, fainting. In men, in very rare cases it may be painful or prolonged erections greater than 4 hours or more. In this case, you must immediately stop using the drug and to require immediate medical attention.
PDE5 inhibitors can cause a serious allergic reaction: hives, swelling, itching, trouble breathing. Sometimes the sudden loss of vision in one or both eyes (NAION) can happen.
Precautions:
Before taking drug from the class of PDE5, tell your doctor about your medical history. Your doctor or pharmacist should to know about your health problems. PDE5 inhibitors are not recommended for use with the following diseases: the deformation of the penis, cavernous fibrosis angulation, Peyronie’s disease, myeloma, leukemia, thrombocytopenia, gastric ulcers, retinitis pigmentosa, angina, heart failure, recent myocardial infarction or stroke (within half a year) and arterial hypertension.
Older people should be careful when using this drug, as they may be more sensitive to side effects from this drug.
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